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专利名称：IDENTIFICATION OF BIOLOGICALLY AND
CLINICALLY ESSENTIAL GENES AND GENEPAIRS, AND METHODS EMPLOYING THEIDENTIFIED GENES AND GENE PAIRS
发明人：Vladimir A. Kuznetsov,Efthimios
Motakis,Anna V. Ivshina
申请号：US14301296申请日：20140610
公开号：US20160040221A1公开日：20160211
摘要：A method of obtaining cut-off expression values should be selected so as tomaximise the separation of the respective survival curves of the two groups of patients.Pairs of genes are statistically significant genes are generated by generating a pluralityof models, each of which represents a way of partitioning a set of subjects based on theoptimal cut-off expression values of the pair of genes. Those gene pairs are identified forwhich one of the models has a high prognostic significance. Novel survival significant genesets forming functional modules which could be used to develop specific prognostic andpredictive tests are derived.
申请人：Agency for Science, Technology and Research
地址：Singapore SG
国籍：SG
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